MTHFR Gene Symptoms and Supplements
© All rights reserved.

MTHFR

MTHFR enzyme converts dietary folate and synthetic folic acid into l-methyl folate, which plays a key role in synthesising neurotransmitters. Some people have a copy of the C677T MTHFR gene, resulting in a 35% reduction in heterozygotes activity and a 70% decrease in homozygotes activity. People with this mutation will have less ability to produce l-methyl folate.

MTHFR Gene Mutation Symptoms

Effects of MTHFR variants vary from one person to another, and symptoms can vary from barely noticeable changes in overall health to long-term health problems. Research has shown a link between MTHFR mutations and numerous health issues, including autism, cardiovascular disease, colon cancer, hormonal issues like PCOS, schizophrenia, ADHD, chronic fatigue, migraines, autoimmune disease, thyroid and digestive issues. Research shows a link between MTHFR mutations and anxiety, depression, and other mental health disorders. MTHFR produces an important enzyme that converts folate into a form that plays a key role in mood-regulating neurotransmitters production.

MTHFR Supplements

Folic acid

Folic acid supplementation may compensate for the decreased activity of the MTHFR enzyme, resulting in normal l-methyl folate levels, affecting the depression response. Studies found that folic acid supplementation's effect on depression has produced mixed results. There have been further studies to investigate the folic acid supplementation effects in combination with antidepressants, but again the results are mixed, with some studies showing improved depression and others, including meta-analysis, with no clinical benefit. There are currently no studies examining the MTHFR C677T genotype in depressed patients taking folic acid supplementation.

L-methyl folate

Taking L-methyl folate alone or in addition to an antidepressant improves depression. Only one study examined the MTHFR C677T genotype in depressed patients taking L-methyl folate supplementation. The study did not find any significant improvement on the HDRS-28 scale for any MTHFR genotype. However, the study sample was small, and patients with MTHFR mutation benefited more from L-methyl folate supplementation. Having said the above another symptom some may face with MTHFR is gut health issues. If you are facing gut health issues it is highly recommended to add methyl-life’s Mega SporeBiotic™ to improve gut health.

There are currently no guidelines on the folic acid or l-methylfolate dosage. For folic acid, the multivitamin usually contains 400 mcg, and the prenatal vitamin contains 800 mcg. L-methyl folate is available over the counter or as a prescription only. Although the study found mixed results, some caution is needed in using folic acid’s high doses, as it may mask vitamin B12 deficiency. Furthermore, some studies suggest that a high intake of folic acid may increase the neurological effects of vitamin B12 deficiency. Your healthcare professional should weigh the benefits of L-methyl folate and folic acid supplementation with the potential risks linked with these treatment strategies.

Natural Treatment for MTHFR mutations

To decrease inflammation, detox pathways burden and elimination system eat only unprocessed or minimally processed foods. It will help to prevent synthetic folic acid used in processed foods. Improve your gut health and eat organic foods. Consuming a balanced diet and maintaining a healthy weight help to treat MTHFR. Eliminate your alcohol consumption and avoid smoking. Remove all household and environmental toxins. Reduce your stress. Consider taking methylated vitamins as a supplement. Help detoxify by consuming enough water, sweat through exercise, eating a healthy diet, and brushing your dry skin.

Author(s): SAAD MUHAMMAD
Published at: 19 Mar 2022 10:48 GMT
Original link (login required): https://ilde.upf.edu/pg/lds/view/286043/